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The present observations were done on human beings, the healthy and the patients suffering from the kakke as well. The chief data may be summarized as follows. 1. Youths, who neglect physical exercise, apt to suffer from the kakke, if the nutritious conditions, especially the amount of the- vitamin B, be taken practically same to those who remain quite healthy; 2. Disaccharide, as milk sugar, does not effect any development of the disease, while polysaccharide as starch, taken in the amount to furnish the same amount of fuel value, acts to produce it. 3. Unpolished rice, if it will be cooked for a long time in the form of gruel, cannot effect to cure the kakke, while rice-bran, made vitamin B free by means of alcohol, acts to lessen the disease. Such outcomes apparently give us some warnings against taking the deficiency of vitamin B as the sole cause of the kakke disease, as several authors commonly assume, the various materials, pathological and clinical as well, put forwarded by a number of authorities in Tokyo, etc. what are concisely presented above, being taken also into account.

Some Remarks r_??_ the Etiology of the Kakke Disease