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1. The lasting preparation of the denervated heart was made on dogs with intact suprarenal medulla, and those medulli-suprarenal-ectomized. The animal was cooled by immersion of its body into the cold bath, until its body temperature fell to below 30°C. and the effects upon the heart rate, the blood pressure, and the body temperature etc. were noted. 2. On cooling the animal excessively, the heart was first accele-rated and then decreased in both kinds of animals along with the fall in the body temperature. The magnitude of increase was clearly great and the decrease was slight in the animals with intact supra-renal medulla, as compared with those in the demedullated animals. In the former the basal rate of the denervated heart was almost regain-ed at the rectal temperature 29° to 32.5°C., while in the latter it was regained at 34.5° to 36°C. After returning to the basal, the heart rate remained generally at this or a little higher rate, while the body tem-perature rose further continuously towards the original. In the me-dulli-suprarenalectomized dogs the blood pressure after withdrawal from the cold bath soon underwent a more or less marked fall, instead of remaining at a high level as in those with intact suprarenal me-dulla. 3. Thus it was proved that the demedullation of the suprarenal glands modified the reaction of the dogs with the denervated heart to severe cooling as regards the heart rate, the arterial blood pressure and the body temperature: the preliminary, temporary rise in the heart rate as well as-in the blood pressure was reduced, and the slowing of the heart which had taken placed already during the cooling and fur-ther continued after stopping it, was exaggerated and prolonged. Such modifications in the reaction are explainable on the fact, as reported previously, that severe cooling produces a large acceleration in the epinephrine output from the suprarenal glands.

Effect of Severe Cold upon the Rate of the Denervated Heart of Non=Anaesthetized Dogs and the Epinephrine Secretion