English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The epinephrine output rate, blood pressure and blood sugar concentration were studied after giving morphine in dogs which were proved as tolerant against it, judging from the narcotic state by the previous treatment with it, and compared with those obtainable when the dog had not been previously treated with morphine or had not obtained any tolerance. The suprarenal vein blood was collected according to the method of Satake et al., without disturbing the behaviour of the animal, its epinephrine concentration being determined by the rabbit intestine segment method. The blood sugar and blood pressure were simultaneously measured. Intravenous injection of 8 mgrms. morphine per kilo of body weight in a 2 per cent solution was, in the normal dogs, followed by an immediate fall in blood pressure with a profound narcosis. The blood pressure usually reached itslowest level such as 10-30 mms. Hg. with-in one or one and a half minutes after the start of injection, the preinjection level being recovered almost completely within two hours. The epinephrine output rate was increased ; the greatest rate, which was determined 4-5 minutes after injection, was 0.0003-0.00, 05 mgrm. per kilo per minute from one gland as compared with 0.00002-0.00004 mgrm. per kilo per minute before injection. The hypersecre-tion lasted much longer than the period of the lowering of blood pres-sure. The bradycardia appeared in the later stage of the observation. The blood sugar was also increased ; its highest level being reached within 15-60 minutes. When the animal acquired a full tolerance to the narcotic effects, the circulatory, hyperglycaemic as well as hyperepinephrinaemic effects of morphine did not occur. The bradycardia occurred no more.

The Effect of Morphine Administration upon the Output Rate of Epinephrine, Blood Sugar Level and Blood Pressure in Normal and Tolerant Dogs