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Some tumor cells such as YAC-1 and RL male 1 were killed by mouse peritoneal macrophages elicited with OK-432 one day before the harvest. The killing reactions were inhibited specifically by anti-Mac-1. The results suggest that some macrophages generated early after the injection of OK-432 kill tumor cells with the aid of CR3.

Involvement of Mac-1 antigen in tumor cell killing by macrophages.