English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effect of iron in different forms on the proliferative response to mitogen and ferritin content of human mononuclear leukocytes (MNL) was studied in vitro. Iron-loaded transferrin (FeTF) but not apotransferrin (apoTF) significantly enhanced the mitogenic response of MNL in serum-free culture. Removal of TF from serum markedly reduced its effectiveness as a serum supplement. This effect could be almost totally reversed when the serum was reconstituted with both iron and apoTF. Four forms of iron showed a stimulatory effect on ferritin synthesis in MNL in the increasing order: FeTF less than iron nitrilotriacetate less than iron citrate (molar ratio 1:20) less than iron citrate (1:1). The effect appeared to be correlated with their susceptibility to polymerization in aqueous solution. It is proposed that iron may a) enhance the mitogenic response of MNL, due probably to the physiological form of iron, FeTF, and b) stimulate ferritin synthesis, a protective reaction of the cell to toxic polymerized forms of the metal.

Physiological and non-physiological forms of iron affect differently proliferation and ferritin synthesis in human mononuclear cells in vitro.