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Sterol and DNA syntheses were induced in human peripheral blood lymphocytes stimulated with phytohemagglutinin (PHA). DNA synthesis in the PHA-stimulated lymphocytes was suppressed by 7 alpha-hydroxycholesterol (7 alpha-HC). The maximum suppression of DNA synthesis was observed when 7 alpha-HC was added in the culture within 6 hr of PHA stimulation to the lymphocytes. However, as the concentration of fetal bovine serum (FBS) in the culture medium was increased, the inhibitory effect of 7 alpha-HC on the syntheses of sterol and DNA were decreased. Furthermore, low and high density lipoproteins completely reversed the inhibition of DNA synthesis by 7 alpha-HC. These results suggest that cholesterol is an essential requirement of lymphocyte blastogenesis regardless of whether the source of the sterol is exogenous or endogenous.

Inhibition of sterol and DNA syntheses in phytohemagglutinin-stimulated human lymphocytes by 7.ALPHA.-hydroxycholesterol.