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Electromyographic responses of the canine-pyeloureter to dobutamine, a beta 1-adrenoceptor agonist were investigated in vitro. Dobutamine produced a marked enhancement of potential in the pelvicalyceal (PC-) border, but failed to evoke noticeable responses in the renal pelvis and ureter. Dobutamine, however, made the pacemaker rhythm a little slow. This finding shows that the renal pacemaker is somewhat different form the cardiac pacemaker, pace of which is quickened by dobutamine.

Response of the renal pacemaker to .BETA.1-adrenoceptor agonist: Difference from the cardiac pacemaker.