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A spectrophotometric study for serum N-acetyl-beta-glucosaminidase activity in patients with different types of epidermolysis bullosa and other bullous diseases was carried out. The activity in recessive type of epidermolysis bullosa dystrophica was higher than in dominant type of epidermolysis bullosa dystrophica and other bullous diseases. High levels of this enzymatic activity may be related to the metabolism of glycosaminoglycans, especially hyaluronic acid in recessive type of epidermolysis bullosa dystrophica.

N-acetyl-.BETA.-glucosaminidase activity in serum of patients with epidermolysis bullosa.