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A rare variant (-D-/-D-) in two generations due to consanguineous marriage was reported. The propositus (T.M., 27 years of age) delivered her second baby who suffered from severe jaundice. She had agglutinin of titer 1:64 in saline and 1:1,024 in Coomb's test against red cells of her husband (CDe/cDE). Family study revealed that T.M.'s father and his two siblings were grouped as -D-/-D-. Each of the siblings (both females, 53 and 46 years of age) had three children who were delivered normally without hemolytic disease. No agglutinin concerning the Rh-Hr system was detected in the sera of the siblings.

A family study of an extremely rare Rh-Hr variant (-D-/-D-) in two generations.