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Effects of prednisolone on the biochemical indices of blood serum, ash content in bones, calcium absorption and calcium-binding protein (CaBP) in the intestinal mucosa were studied. The oral administration of prednisolone (10 mg/kg) for 2 weeks reduced CaBP content and calcium absorption to the level typical for D-avitaminosis. The oral administration of 1 alpha-hydroxycholecalciferol (390 pmoles/day) in combination with prednisolone for a week returned calcium absorption and CaBP to the control value.

Reversal of prednisolone-induced inhibition of intestinal calcium-binding protein synthesis by 1.ALPHA.-hydroxycholecalciferol in chicks.