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The antihypertensive mechanism of orally active angiotensin I-converting enzyme inhibitor, SQ 14225 (SQ), in low renin hypertension was investigated. In the SQ-responder with low renin hypertension, the hypotensive effect of SQ was abolished after the inhibition of endogenous prostaglandin (PG) synthesis with indomethacin, while no significant change in blood pressure was found in the SQ-responder with normal renin hypertension. These results suggest that SQ may potentiate the vasodilating PG system, contributing to the antihypertensive mechanism in SQ responders with low renin hypertension.

Indomethacin inhibits the antihypertensive effect of Captopril, SQ 14225, in low renin hypertension.