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Immunoglobulin classes of antibodies to salmon sperm deoxyribonucleic acid (ssDNA) induced by heat-denatured ssDNA-methylated bovine serum albumin (MBSA) conjugates were separated and characterized, and an anamnestic response to the conjugates was reinvestigated. (1) Antibodies to ssDNA were present in both IgM and IgG. On the contrary, antibodies to polyA•polyU and polyI•polyC occurred exclusively in IgG. (2) IgM and IgG were purified by appropriate combinations of gel filtration, ammonium sulfate fractionation, sucrose density centrifugation and DEAE-cellulose chromatography, and their antibody activities were reconfirmed. (3) A single dose of a ssDNA-MBSA complex did not induce primary antibody synthesis in rabbits, but booster injections elicited the antibody. One year after stopping the booster injection, the immunological memory for antibody production almost disappeared, and the antibody producing capacity fell remark-ably.

Separation and Characterization of Immunoglobulin Classes of Anti-Salmon Sperm Deoxyribonucleic Acid Antibodies in Rabbits