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Cold atmospheric plasma (CAP) is a promising option for the treatment of node assay (according to the Organisation for Economic Co-operation and Development protocol) to evaluate the kINPen MED’s potential to trigger skin sensitization. Our results showed that 25 s of CAP exposure did not induce skin sensitization compared with the vehicle control (acetone/olive oil mixture). The CAP-treated group had a stimulation index (SI) of 0.76, which device did not cause any harmful sensitization or irritation in a murine model.

Repeated Cold Atmospheric Plasma Application to Intact Skin Does Not Cause Sensitization in a Standardized Murine Model