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Exposure and sensitization to cockroach allergens is an important risk factor for allergic disease in humans. Despite a recent burgeoning of clinical and socioeconomic studies regarding environmental pervasiveness and human exposure to cockroach allergens, little is known about the basic biology of these proteins. The purpose of this study was to ascertain gene expression patterns and the tissue distribution of Blattella germanica allergen 1 (Bla g 1), a perennial indoor environmental allergen, thought to be involved in digestion in cockroaches. We also investigated the relative potential contribution of different life stages of the German cockroach to environmental Bla g 1. Enzyme-linked immunosorbent assay was used to quantify the Bla g 1 contents of feces and various anatomical tissues, and Northern blot analysis was used to elucidate tissue-specific expression of Bla g 1. Results showed that the Bla g 1 protein is most prevalent in the midgut, and the Bla g 1 gene is exclusively expressed by midgut cells. Although Bla g 1 is produced by both sexes and all life stages of the German cockroach, adult females produce and excrete significantly more Bla g 1 in their feces than males or nymphs, even when corrected for body mass or mass of voided feces. Our results show that the concentration of Bla g 1 in feces of adult females is 6- to 7- and 30-fold higher than in adult males and nymphs, respectively, probably because females process more food than other life stages of the German cockroach.

journal of medical entomology

Gene Expression and Tissue Distribution of the Major Human Allergen Bla g 1 in the German Cockroach,<i>Blattella germanica</i>L. (Dictyoptera: Blattellidae)

Gene Expression and Tissue Distribution of the Major Human Allergen Bla g 1 in the German Cockroach,Blattella germanicaL. (Dictyoptera: Blattellidae)