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The aim of the present study was to evaluate the influence of different doses of nandrolone decanoate (ND) associated with Strength Training (ST) on the phenotype of fibers and cross-sectional area (CSA) of the extensor digitorum longus (EDL) in Wistar rats. The animals were divided into seven groups: control (CG) and the groups according to the dose of ND administered (0,1, 1, 2, 5, 10 e 20 mg/kg). The ST consisted of water jumping with loads of 50-70% of their body mass, three times per week during five weeks. The association of ST with ND promoted a modulatory role on the muscle fiber types. There was a hypertrophy of fast twitch fibers (type II) as compared with slow twitch (type I). In conclusion, although the association of ST with ND increased muscle CSA and modified fiber phenotype, there was no additional effect of higher doses.O presente estudo avaliou a influência de diferentes doses de decanoato de nandrolona (DN) associado ao Treinamento de Força (TF) sobre o fenótipo de fibras e área de secção transversa (AST) do músculo extensor longo dos dedos (EDL) em ratos Wistar. Os animais foram divididos em sete grupos: controle (GC) e grupos de acordo com a concentração de DN (0,1, 1, 2, 5, 10 e 20 mg/kg) administrada intramuscular 3 vezes/semana. O TF consistiu de saltos em meio líquido (carga 50-70% do peso corporal) 3x/semana, durante cinco semanas. A associação do TF e DN promoveu ação modulatória sobre os tipos de fibras. Houve hipertrofia das fibras de contração rápida (tipo II) em comparação com as fibras de contração lenta (tipo I). Em conclusão, apesar da associação do TF com DN aumentar a AST muscular e alterar o fenótipo das fibras, não houve efeito gradual das doses mais altas

Efeito de diferentes doses de nandrolona associado ao treinamento de força sobre o perfil fenotípico e área de secção transversa do músculo de ratos