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We read with great interest the well-written manuscript by Melo et al.,(1) who analyzed clinical and radiological findings that influence the pathological diagnosis of solitary pulmonary nodule (SPN). They concluded that advanced age, greater maximum SPN diameter, and spiculated margins were significantly associated with the diagnosis of malignancy. For radiologists and pulmonologists, SPNs continue to represent a major diagnostic challenge. Recent technological advances in imaging techniques and the widespread use of CT have increased the frequency of pulmonary nodule detection.(2) Small nodules (1-2 mm in diameter) are commonly detected on CT images, and their clinical importance appears to differ markedly from that of larger nodules identified on chest X-rays.(2) Thus, this enhanced detection has not affected the basic issue of distinguishing the status of a nodule, whether benign (requiring no specific approach) or indeterminate (potentially malignant),(2) and most nodules are resected for diagnosis and determination of the appropriate treatment.(3) Pulmonary lymph nodes are a common and underrecognized cause of a peripheral SPN. These lymph nodes are usually found at the bifurcation of the bronchi, before the fourth branch, where they are referred to as peribronchial lymph nodes. Lymph nodes are occasionally present within the lung parenchyma, where they are designated intrapulmonary lymph nodes (IPLNs)(3) or perifissural nodules (PFNs). The differentiation of IPLNs from other small pulmonary nodules on CT images is difficult although clinically important. In particular, the misinterpretation of a radiologically detected IPLN as a separate tumor nodule leads to overstaging and possible exclusion from indication for surgical treatment in patients with primary lung cancer. (3) Several tomographic characteristics may aid in the differential diagnosis of an IPLN (Figure 1). These lymph nodes are oval, round, triangular, or trapezoidal, with sharply defined borders; they are almost always located below the level of the carina, predominantly in the subpleural regions of the lower lobes. They are frequently attached to the pleura or separated from the pleural surface by a few millimeters.(3-5) IPLNs have thin linear attachments extending from the nodule to the pleura. These linear densities have been shown to represent ectatic lymphatic channels.(5) De Hoop et al.(6) recently reported that the growth rates of PFNs can reach those of malignant nodules, but no PFN in their study was malignant. In conclusion, IPLNs are benign features that should be taken into consideration in the differential diagnosis of an SPN. Their identification might reduce the number of unnecessary surgeries and follow-up examinations.

Intrapulmonary lymph node: a common and underrecognized tomography finding