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To assess blockade of matrix metalloproteinase (MMP)-2 and MMP-9, as well as the variation in FEV1, in patients with lymphangioleiomyomatosis (LAM) treated with doxycycline (a known MMP inhibitor) for 12 months.

Doxiciclina em pacientes com linfangioleiomiomatose: biomarcadores e resposta funcional pulmonar