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Determining factors of the neuronal viability in hippocampal slices from patients with mesial temporal lobe epilepsy The aim of the present research was to investigate the determining factors of neuronal viability in hippocampal slices from TLE patients submitted to hippocampectomy in the Hospital São Paulo between 2002 and 2005. The following variables were investigated: age, epilepsy duration, seizure frequency, hippocampal atrophy, resection time, history of initial precipitant injury (IPI) and surgical outcome according Engel’s classification. We compared patients who hippocampal slices showed a preserved neuronal viability during in vitro electrophysiological recordings (“ALIVE” group) and those who hipocampal slices did not produce electrical recordings (“DEAD” group). There was no statistical difference between the two groups regarding patient’s age (p = 0,84), epilepsy duration (p = 0,71), resection time (p = 0,66) and history of IPI (p = 0,42). On the other hand, there were statistically significant differences regarding hippocampal volume (p = 0,0005), asymmetry index (p = 0,01) and seizure frequency (p = 0,008). These data suggest that very atrophic hippocampi, from patients with low seizure frequency, are likely to present a disruption of neuronal viability.

Fatores determinantes da viabilidade neuronal em fatias hipocampais de pacientes com epilepsia do lobo temporal mesial