English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Egletes viscosa Less (Asteraceae), popularly known as "macela" or "macela-da-terra", is a plant widely used in popular medicine due to its anti-inflammatory, bactericidal, antidiarrhoea, mio-relaxant, antispasmodic, antinociceptive, digestive, and anti-viral properties. Phytochemical screening of aqueous extract of Egletes viscosa (AEEV) revealed the high presence of flavonoids. This study examined the oral antinociceptive potential of AEEV in rodents using different concentrations (100, 200, and 400 mg/kg, p.o.). The results showed significant antinociceptive action when tested in writhing (200 and 400 mg/kg-p<0.05) and in the second phase of formalin tests (200 mg/kg-p<0.01 and 400 mg/kg-p<0.001). The inhibition (%) of extract in the writhing test was 63.4, 56.7, and 79.2% respectively for 200, 400, and acetyl salicylic acid (300 mg/kg); for the formalin test (second phase) results were 66.1, 84.7, and 96.2% respectively for 200, 400, and acetyl salicylic acid (300 mg/kg). Collectively, these observations suggest that AEEV is effective against continuous inflammatory pain. AEEV was well tolerated. In an acute toxicity test, oral administration of 5 g/kg of AEEV was performed and no mortality rate was observed. Similarly, in a subchronic toxicity study, no mortality was observed after 30 days of daily oral administration of 100 mg/kg of AEEV. There was no significant difference in the body and organ weights between control and experimental animals in both acute and subchronic toxicity tests. Pathological assays did not reveal any evidence of detectable differences in the gross appearance, as well as in the architectural or cellular pattern characteristics of the internal organs of the animals in both acute and subchronic tests. Nevertheless, significant differences were verified between males of the experimental and control groups regarding the levels of hemoglobin and leukocytes. In conclusion, AEEV did not induce any hazardous effects on the majority of the parameters studied. Additionally, an antinociceptive activity of the extract was verified. However, the increase in the levels of hemoglobin and leukocytes should be investigated in more detail. Egletes viscosa Less (Asteraceae), popularmente conhecida como "macela" ou "macela-da-terra", é uma planta largamente usada na medicina popular devido as suas propriedades: anti-inflamatória, bactericida, antidiarréica, mio-relaxante, anti-espasmódica, antinociceptiva, digestiva e anti-viral. Análise fitoquímica do extrato aquoso da Egletes viscosa (AEEV) mostrou elevada presença de flavonóides. Este estudo examinou o potencial antinociceptivo do AEEV em roedores usando diferentes concentrações (100, 200 and 400 mg/kg, p.o.). Os resultados mostraram significante efeito antinociceptivo quando testadas as doses (200 mg/kg-p<0.01; 400 mg/kg-p<0.05) e na segunda fase dos testes com formalina (200 and 400 mg/kg-p<0.001). Este efeito antinociceptivo foi similar ao ácido acetilsalicílico (300 mg/kg) nas doses de 200 e 400 mg/kg. Adicionalmente, estas observações sugerem que o AEEV é efetivo contra dores inflamatórias contínuas. AEEV foi bem tolerada. No teste de toxicidade aguda, utilizando uma administração oral de 5 g/kg de AEEV, não foi observado casos de mortalidade. Da mesma maneira, no estudo subcrônico nenhuma mortalidade foi observada após 30 dias de administração oral diária de 100 mg/kg do AEEV. Não houve diferença significativa entre os pesos corporal e dos órgãos isolados quando comparados grupo controle e teste tanto no estudo agudo quanto subcrônico. Ensaios histopatológicos não revelaram diferenças entre a aparência dos tecidos, assim como na estrutura celular dos órgãos dos animais do estudo agudo e subcrônico. No entanto, diferenças significativas foram verificadas entre os machos do grupo experimental e controle quanto à hemoglobina e leucócitos. Conclui-se que o extrato estudado não induziu nenhum risco na maioria dos parâmetros avaliados e, ainda, mostrou efeito antinociceptivo. No entanto, o aumento dos níveis de hemoglobina e leucócitos devem ser melhor investigados

Antinociceptive activity and toxicological study of aqueous extract of Egletes viscosa Less (Asteraceae)