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Papain is a thiol proteolytic enzyme widely used in dermatology that found applications in wound treatment. Recently, papain was also used as absorption enhancer which can modify the peptide/protein material in the bilayer domain. We investigated papain safety using human skin that was exposed to papain in vitro at different times: 4, 24 and 48 hours. The samples were examined using Light and Transmission Electron Microscopy (TEM) to study of the mechanisms involved in enhancer-skin interaction. After 24 hours, changes occurred in corneosomes. However, samples of 48 hours did not show major changes in agreement with the control. These findings indicated that papain could be used safely onto the skin. Papaína é uma enzima proteolítica amplamente utilizada na dermatologia para o tratamento de feridas. Atualmente, a papaína também tem sido empregada como promotor de absorção cutânea passível de modificar os domínios protéicos da epiderme. Nesta pesquisa investigou-se in vitro a segurança da papaína, utilizando pele humana exposta a enzima em diferentes períodos de tempo de contato: 4, 24 e 48 horas. As amostras foram avaliadas por Microscopia de Luz e Eletrônica de Transmissão (MET), técnicas que podem ser utilizadas no estudo dos mecanismos envolvidos na interação de promotores de absorção cutânea e a pele. Após 24 horas de contato entre a pele a solução de papaína, mudanças ocorreram nos corneossomos, no entanto, as amostras em contato por 24 horas não evidenciaram alterações relevantes comparadas com o controle. Os resultados indicaram que a papaína poderia ser seguramente aplicada sobre a pele

In vitro safety assessment of papain on human skin: A qualitative Light and Transmission Electron Microscopy (TEM) study