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The combination of fed-batch processes and low cost substrates (sugar cane juice and urea) was studied in view of the optimization of biomass and astaxanthin production by the yeast Phaffia rhodozyma ATCC 24202. In the optimized process, a biomass and astaxanthin productivity of 0.327 g/l/h and 0.124 mg/l/h was achieved, respectively. Compared to the batch process studied, an increase of approximately 4.55-fold in the biomass productivity and 4.73-fold in the astaxanthin productivity was found. A combinação de processos descontínuo alimentado e matérias-primas de baixo custo (caldo de cana-de-açúcar e uréia) foi estudada a fim de otimizar a produção de biomassa e astaxantina pela levedura Phaffia rhodozyma ATCC 24202. No processo otimizado, produtividades em biomassa e astaxantina de 0,327 g/L/h e 0,124 mg/L/h foram obtidas, respectivamente. Comparadas com o processo descontínuo estudado, verificou-se aumento de 4,55 vezes na produtividade em biomassa e 4,73 vezes na produtividade em astaxantina

Optimization of biomass and astaxanthin production by the yeast Phaffia rhodozyma