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Leaves from several Passiflora species are largely employed in the Brazilian folk medicine as anxiolytic and sedative. In this work the anxiolytic, sedative-like properties and liquid chromatography analysis of methanolic extract of Passiflora actinia were evaluated. The methanol extract and all of its fractions presented significant sedative-like effect in elevated plus-maze and open field tests. Only the aqueous fraction of the methanol extract showed selective anxiolytic activity (30 mg/kg). Chromatographic analysis of the active fractions showed the presence of isovitexin and absence of the classical Passiflora beta-carboline alkaloids or flavonoids such as vitexin, rutin, swertisin, hesperidin and orientin. The tincture obtained from P. actinia leaves presented 0.27 mg/ml of isovitexin and absence of vitexin. Folhas de diversas espécies de Passiflora são amplamente empregadas na medicina popular brasileira como ansiolítica e sedativa. Neste trabalho, as propriedades ansiolíticas e sedativas e análise por cromatografia líquida dos extratos metanólicos de Passiflora actinia foram avaliados. O extrato metanólico e todas as suas frações apresentaram efeitos sedativos significativos nos testes de labirinto em cruz elevada e campo aberto. Somente a fração aquosa do extrato metanólico mostrou seletiva atividade sedativa (30 mg/kg). Análise cromatográfica das frações ativas mostraram a presença de isovitexina e ausência dos alcalóides beta-carbolínicos clássicos de Passiflora ou flavonóides como vitexina, rutina, swertisina, hesperidina e orientina. A tintura obtida de P. actinia (folhas) apresentou 0,27 mg/ml de isovitexina e ausência de vitexina

Sedative and anxiolytic effects of methanolic extract from the leaves of Passiflora actinia