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This study was carried out to investigate the effects of adding baker yeast (BY), chlortetracycline (CTC) and both BY + CTC to a control diet containing 200 ng/g of aflatoxin B1 (C + AFB1) on performance, serum parameters and pathologyc alterations of broilers. A total 100 chicks (Ross PM 3) were divided into five groups in individual cages and each containing 20 animals. BY, a rich source of protein and vitamin B complex, was mixed into the diets at 2.0 %, CTC was mixed into the diet at 2.5 ng/g. Feed consumption, body weight and feed efficiency were recorded weekly. Serum parameters and pathologyc alterations were determined at the end of the study. Dead animals were recorded daily. Liver changes were clearly apparent in the C+AFB1and C+ AFB1+CTC most of the livers were enlarged, yellow and had pethecial hemorrhages. Canalicula cholestosis was absent in group C+AFB1 and C+ AFB1+CTC, but not others. When compared to the control (C) group, alkaline phosphatase (ALP), appear to be significantly increased in the C+AFB1 and C+CTC+ AFB1 groups. Serum glutamic oxalacetic transaminase (GOT)was increased in C+AFB1 birds. Serum alphaphetoprotein was not affected by the treatments. Feed consumption and body weight were significantly reduced in group AFB1. Birds receiving BY + AFB1, CTC + AFB1 and BY + CTC + AFB1 had a significantly higher body weight than group C+AFB1. Feed efficiency was better in group CTC + AFB1 than the others. The findings of this research suggest tha BY (2%) can partly counteract some of the toxic effects of AFB1. Este estudo foi desenvolvido para avaliar os efeitos da adição de Levedura de panificação (BY) e cortetraciclina (CTC) e ambos BY+CTC a uma dieta controle © contendo 200 ng/g de aflatoxina B1 (C+AFB1) sobre desempenho, parâmetros séricos e alterações patológicas de frangos de corte. Um total de 100 pintinhos (Ross PM3) foi dividido em cinco grupos, em gaiolas individuais, contendo 20 animais para cada grupo. A levedura de panificação, uma fonte rica de proteína e vitamina do complexo B foi adicionada à dieta, à porcentagem de 2% e a CTC, a 2.5 ng/g. Consumo alimentar, peso corporal e eficiência alimentar foram registrados semanalmente. Parâmetros séricos e alterações patológicas foram determinados no final do estudo. Animais mortos foram registrados diariamente. Alterações ocorridas no fígado foram claramente aparentes nas dietas C+AFB1 e C+AFB1+CTC, sendo que a maioria dos fígados apresentou-se aumentado, amarelo e com hemorragia peticial. Canícula colestoses foi ausente nos grupos C+AFB1 e C+AFB1=CTC, mas não nos demais grupos. Quando comparado com o grupo controle©, alcalino fosfatase (ALP), parece que houve aumento significativo nos grupos C+AFB1 e C=CTC=AFB1. Oxaloacético tansaminase glutâmico (GOT) sérico foi maior no grupo de aves C+AFB1. Alphafetoproteína sérica não foi afetada pelos tratamentos. Consumo alimentar e peso corporal foram significativamente reduzidos no grupo AFB1. Animais que receberam BY+AFB1, CTC+AFB1 e BY+CTC+AFB1 tiveram aumento significativo no peso corporal, comparado com o grupo C+AFB1. A eficiência alimentar foi melhor no grupo CTC+AFB1 em comparação aos demais. Os resultados desta pesquisa sugerem que BY (2%) pode parcialmente neutralizar alguns dos efeitos tóxicos do AFB1

Reduction of toxic effects of aflatoxin B1 by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicks diets