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O lúpus eritematoso sistêmico (LES) é uma doença crônica que acomete principalmente mulheres entre a terceira e quinta década de vida, multissistêmica, freqüentemente afetando os rins e o sistema nervoso central. Os sintomas relacionados ao trato gastrintestinal, apesar de comuns, quando ocorrem abrindo o quadro clínico, raramente levam ao diagnóstico por causa de sua baixa especificidade. Foi relatado um caso de LES cuja manifestação inicial foi diarréia crônica. Systemic Lupus Erythematosus (SLE) is a chronic multissystemic disease that compromises women between the third and the fifth decade and frequently evolves the kidneys and the central nervous system. Gastrointestinal symptoms are usual however, when they appear as first symptoms, they rarely lead to lupus diagnosis for its low specificity. We report a case of SLE in which the initial manifestation was diarrhea

Diarréia como manifestação inicial de lúpus eritematoso sistêmico