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Mathematical modeling of supercritical fluid extraction of oil from canola and sesame seeds with a two-phase model was performed in this work. A model based on differential mass balance was used to correlate the experimental data. Different adsorption isotherm models (Henry, Freundlich and Brunauer, Emmet and Teller (BET)) were used to describe the equilibrium state. Three model parameters such as effective diffusivity (Deff), mass transfer coefficient (Kf) and axial dispersion coefficient (Dax) of the bed were used as fitting parameters. The experimental data for yields were obtained at pressures of 10-20 MPa, temperatures of 313-333 K and solvent flow rates of 2-4 g/min. From the results, a nonlinear adsorption isotherm exhibited better agreement with experimental data of yield than a linear model in the range of studied conditions.