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JUSTIFICATIVA E OBJETIVOS: Determinar as características clínicas, epidemiológicas e laboratoriais, bem como a mortalidade dos pacientes adultos com sepse, admitidos na UTI geral de hospital privado terciário do estado de Pernambuco. MÉTODO: Estudo tipo coorte prospectiva e observacional, que incluiu pacientes adultos admitidos com o diagnóstico de sepse ou que a desenvolveram durante a internação na UTI do Hospital Português de Recife durante o período de seis meses. Foram colhidos dados clínicos e laboratoriais, bem como, calculados os escores APACHE II e SOFA, sendo os pacientes re-avaliados ao final da internação para definir o desfecho clínico, ou seja, para alta, óbito, ou transferência da UTI. RESULTADOS: Foram incluídos 199 pacientes, dos quais 112 (56,3%) tiveram alta da UTI. Cerca de 67,8% da população foi composta por idosos (maiores de 65 anos), a média do APACHE II foi de 18,2 ± 6,3 e a média do SOFA no primeiro dia foi de 6,3 ± 3,7. O motivo da internação foi clínico em 85,4% dos casos e em 76,4% dos pacientes existia doença crônica associada. A sepse foi de origem pulmonar em 79,3% dos casos e 40% dos pacientes tiveram o agente etiológico isolado. Observou-se plaquetopenia (plaquetas < 100.000/mm³) em 20,6% dos pacientes, o INR > 1,5 em 42%, o fibrinogênio > 300 mg/dL em 81,7% e a atividade da antitrombina < 70% em 32,5% dos casos. CONCLUSÕES: Os dados epidemiológicos de sepse nesse estudo são semelhantes àqueles recentemente descritos em populações no Sul e Sudeste do Brasil, bem como dos Estados Unidos e Europa. BACKGROUND AND OBJECTIVES: Establish the clinical, epidemiological and laboratorial characteristics of septic patients in an intensive care unit (ICU) of a tertiary care private hospital from Pernambuco, in the northeast of Brazil. METHODS: Cohort study without intervention that included adult patients admitted in the ICU with sepsis or that developed it during ICU stay, during a 6-month period. The patients were followed during all ICU stay period. Laboratory and clinical data were collected after sepsis diagnosis. ICU admission APACHE II score and the SOFA score during the three first days after inclusion in the study were collected. RESULTS: The study included 199 patients, of whom 67.8% were older than 65 years of age. More than a half (56.3%) survived the septic episode, mean APACHE II was 18.2 ± 6.3 and mean SOFA score was 6.3 ± 3.7. The disease related to the admission in ICU was medical in 85.4%, and the majority of patients had a chronic associated disease. In 79.3% the lungs were the source of sepsis and in 40% of patients the etiologic agent of sepsis was isolated. Amongst laboratory tests, thrombocytopenia (platelets < 100.000/mm³) was observed on 20.6%, fibrinogen was elevated (> 300 mg/dL) on 81.7%, and the activity of antithrombin was low (< 70%) on 32.5% of patients. CONCLUSIONS: The epidemiology of sepsis in this study, in a private hospital of Recife, was no different from what was recently described in Southeast and South of Brazil, United States and Europe

Características da população com sepse em unidade de terapia intensiva de hospital terciário e privado da cidade do Recife