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O acido 6a,7b-di-hidroxivouacapan-17b-oico (ADV, 1), furanoditerpeno isolado dos frutos de Pterodon polygalaeflorus Benth, apresenta atividade analgesica em modelos laboratoriais utilizando roedores. Visando reunir dados para estudar a acao biologica de vouacapanoides, foram obtidas seis novas amidas derivadas (4-9), contendo grupos alquilaminas no anel furânico, preparadas pela reacao de Mannich com sais de iminios pre-formados. Esses derivados tiveram suas estruturas determinadas pela analise de dados espectroscopicos no IV, RMN de 1H e de 13C e foram submetidos a triagem farmacologica in vitro, destinada a detectar substâncias com acao depressora sobre celulas neuronais.

journal of the brazilian chemical society

Synthesis of 6alpha,7beta-dihydroxyvouacapan-17beta-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation