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Diacetylenic phosphatidylcholines are synthetic compounds analogous to natural phospholipids. These molecules can be hydrated to form bilayered aggregates known as liposomes in a manner similar to natural phosphatidylcholines. A particular feature of these liposomes is their capability of undergoing polymerization when submitted to ultraviolet (UV) light irradiation. This process allows the construction of polymerized liposomes possessing interesting physical properties making these vesicles appropriate for slow-release drug delivering systems. In this article we describe the total syntheses of diacetylenic phosphatidylcholines 1,2-bis(10',12'-heptadecadiynoyl)-sn-glycero-3-phosphatidylcholine (1a), 1,2-bis(10',12'-tricosadiynoyl)-sn-glycero-3-phosphatidylcholine (1b) and 1,2-bis(4',6'-tricosadiynoyl)-sn-glycero-3-phosphatidylcholine (1c). Phospholipids 1a and 1c, displaying the butadiinyl chromophores closer to the chain terminus, or closer to the polar heads respectively, have not been reported before. Noteworthy was the observation that liofilization of the diacetylenic alcohols and acids intermediates significantly reduced undesired polymerization, allowing to stock these compounds for a short period of time (~24 h).Fosfatidilcolinas diacetilênicas são compostos análogos aos fosfolipídios naturais. Tais moléculas podem ser hidratadas formando agregados em bicamadas denominados lipossomas, de maneira semelhante às fosfatidilcolinas naturais. Uma característica particular desses lipossomas é a capacidade dos grupos butadiinos sofrerem polimerização quando submetidos à irradiação com luz ultra-violeta (UV). Este processo possibilita a obtenção de lipossomas polimerizados com propriedades físicas mais apropriadas visando sua aplicação como sistema de liberação controlada de medicamentos. Neste artigo é descrita a síntese total das fosfatidilcolinas diacetilênicas 1,2-bis(10',12'-heptadecadiinoil)-sn-glicero-3-fosfatidilcolina (1a), 1,2-bis(10',12'-tricosadiinoil)-sn-glicero-3-fosfatidilcolina (1b) e 1,2-bis(4',6'-tricosadiinoil)-sn-glicero-3-fosfatidilcolina (1c). Os fosfolipídios 1a e 1c, nos quais o cromóforo butadiinil está localizado próximo ao término da cadeia, ou próximo da cabeça polar, respectivamente, não estão relatados na literatura. Também digna de nota é a observação de que liofilização dos intermediários álcoois e ácidos diacetilênicos, reduz significativamente polimerizações indesejadas, permitindo assim o armazenamento desses compostos por algum tempo (~24 h)

journal of the brazilian chemical society

Synthesis of the diacetylenic phospholipids 1,2-(10',12'-heptadecadiynoyl)-sn-glycero-3-phophatidylcholine and 1,2-(4',6'-tricosadiynoyl)-sn-glycero-3-phophatidylcholine