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With the object of performing a structure-activity relationship study, we have synthesized several analogues of 2-iodohexadecanal [1], a regulator of iodine metabolism in the thyroid gland, differing by the chain length, the nature of the substituent, and/or the terminal functional group.

Synthesis of Analogues of 2-iodohexadecanal, a Regulator of Iodine Metabolism in the Thyroid Gland