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Pacientes portadores de próteses totais, apresentam, com freqüência a chamada estomatite protética, com a qual associa-se Candida albicans determinando a chamada candidíase eritematosa. Assim, procuramos avaliar a suscetibilidade dessa levedura a agentes antifúngicos. A suscetibilidade de dezenove cepas de Candida albicans isoladas de pacientes apresentando estomatite protética foi estudada frente a: um derivado poliênico representado, pela anfotericina B (AnB), e dois derivados azóicos, cetoconazol e miconazol. A atividade antifúngica foi estudada a partir da determinação da concentração inibitória mínima (CIM) e da concentração fungicida mínima (CFM), pela técnica de diluição em ágar. Os resultados obtidos, mostraram baixos valores de CIMs e CFMs (< 0,15 mg/ml) para a AnB frente a todas as leveduras. Para o miconazol e o cetoconazol, foram observadas CIMs invariavelmente £ 4,00 mg/ml; para as CFMs, foram obtidos valores ³ 16,00 mg/ml frente a maioria das cepas. Conclui-se que a AnB apresentou maior ação fungicida in vitro enquanto os azóis demonstraram ação fungistática mas não fungicida. Acreditamos que a pesquisa de novas drogas, principalmente de uso tópico ainda é necessária, a fim de se tratar, com sucesso, a candidíase eritematosa, comumente observada nas chamadas estomatites protéticas. Users of total prosthesis present in general a high frequency of the so called denture stomatitis, associated to erythematous candidiasis. So, we evaluated the susceptibility of oral yeast to three antifungal agents. Strains of Candida albicans isolated from patients with denture stomatitis were evaluated in relation to the susceptibility of the antifungal drugs as amphotericin B (polyenic derivatives), and azole agents as ketoconazole and miconazole. The antifungal activity was evaluated, and the minimal inhibitory concentration (MIC) and minimal fungicide concentration (MFC) were determined utilizing the agar dilution method. The results demonstrated low values for MICs and MFCs (0.15 mg/ml) for AmB in face of all yeast present. For miconazole and ketoconazole, MICs were invariably £ 4.00 mg/ml, while values of the MFC were ³ 16.00 mg/ml for the majority of the strains. We could conclude that AmB presented a major fungicidal action in vitro, while azoles demonstrated a fungistatic but not fungicidal profile. So, we can consider that new drugs, mainly topical ones, are needed to treat lesions related to denture stomatitis, so commonly observed in wearers of dental prostheses

Suscetibilidade a antifúngicos de cepas de Candida albicans isoladas de pacientes com estomatite protética