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Purpose:  To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with  Sedum dendroideum  extract in burn injuries in rats.    Methods:  Seventy-five rats were submitted to burn injury on their back skin: ( C ) untreated; ( F ) with daily topical application of  S. dendroideum extract ; ( M ) with electrospinning membranes of PLA; ( MF10 ) with electrospinning membranes of PLA with 10%  S. dendroideum extract ; ( MF25 ) with electrospinning membranes of PLA with 25%  S. dendroideum extract . Tissue samples were taken after 2, 6 and 14 days of the burn injury and were subjected to histomorfometric analysis of quantification of fibroblasts, collagen fibers, blood vessels, and inflammatory infiltrate    Results:  The histomorphometric analysis showed an increase in the number of fibroblasts, collagen fibers and blood vessels in the burns treated with membranes of PLA, associated or not with the 10% and 25% extract. The extract of  S. dendroideum  promoted the increase of collagen fibers.    Conclusion:  The electrospinning PLA membrane, isolated or associated with the  S. dendrodeum  extract, favored the healing of burn injuries in this experimental model, with an increase of fibroblasts, collagen fibers, and blood vessels.  S. dendroideum  isolated only stimulated the collagenesis.

Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats