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Estudo com o objetivo de verificar a possibilidade de ocorrência de translocação bacteriana para os rins de ratos, após ligadura de colédoco. Foram utilizados 29 ratos Wistar com peso médio de 171 ± 12,6g. Os animais foram divididos aleatoriamente em grupo I (n=14) e grupo II (n=15). Com técnica asséptica, nos ratos no grupo I foi feita ligadura de colédoco com fio de seda nº 3 zeros e no grupo II foi simulada a ligadura com a simples manipulação do colédoco com pinça de Adson ("sham operation"). No 7º dia pós-operatório os animais foram sacrificados e ressecados os rins para exame histopatológico (coloração H.E.) e microbiológico (meios agar sangue e agar MacConkey). Houve crescimento bacteriano de Klebsiela sp em 28,5% dos casos no grupo I e foram observadas alterações histopatológicas significativas no mesmo grupo. As diferenças foram estatisticamente significantes quando foram comparados os 2 grupos (p<0,05). Concluímos que a icterícia obstrutiva em ratos provoca translocação bacteriana para os rins e alterações histopatológicas associadas. Experimental study in order to determine if obstructive jaundice promotes basterial translocation from the gastrointestinal tract to the kidney in rats. We used 29 Wistar male rats weighing 171±12,6g. They were ramdomly separated in goup I (n=14) and group II (n=15) and operated with asseptic technic. The group I underwent common bile ducts ligature with number 000 silk suture, and in group II (control) the common bile ducts were manipulated with Adson forceps, as a sham operation. On 7th postoperative day the rats were killed with an overdose of anesthesic and had their kidneys resected. Portions of each kidney were harvested for quantitation of bacterial translocation and histopatologic examination. The incidance of bacterial translocation was 28,5% (Klebsiella sp) in group I and 0% in group II (p<0,05). Intersticial edema, nephrosis and tubular degeneration were observed in group I and the histology was normal in group II. The authors conclude that obstructive ajundice promotes bacterial translocation to the kidney, associted to histopatological alterations in this organ

Translocação bacteriana para o rim na icterícia obstrutiva experimental