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Plants with medicinal properties have been applied for a long in the traditional health care, so that sometimes their use takes place concomitantly to the use of industrialized drugs. The aim of this study was to evaluate the interference of Plectranthus amboinicus essential oil on the anti-Candida activity of some clinically used antifungals by the solid medium diffusion procedure. Assayed antifungals were amphotericin B (100 µg/mL), ketoconazole (50 µg/mL) and itraconazole (50 µg/mL). C. albicans, C. tropicalis, C. guilliermondii, C. krusei and C. stellatoidea were used as test microorganisms. P. amboinicus essential oil showed MIC value for most assayed yeast strains. The essential oil when assayed in its MIC value showed some interference on the anti-Candida effectiveness of the assayed antifungals. It was noted yeast growth inhibition zones with different diameters when the antifungals were tested alone and combined with the essential oil. P. amboinicus essential oil showed prominent interference on the anti-yeast activity of itraconazole providing a synergic effect on C. albicans, C. tropicalis, C. krusei and C. stellatoidea. Also, the essential oil interfered on the anti-yeast activity of ketoconazole when interacting with C. albicans, C. guilliermondii and C. stellatoidea providing, respectively, an antagonic and synergic effect. On the other hand, it was found a small interference on the anti-yeast effect of amphotericin B. These data showed that combined use of medicinal plants and/or derivatives with industrialized drugs, particularly antimicrobials, could interfere on their expected therapeutic effects

Interference of Plectranthus amboinicus (Lour.) Spreng essential oil on the anti-Candida activity of some clinically used antifungals