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This was a double-blind, placebo-controlled, community-based trial. For 16 weeks, children in the intervention group (n = 180) received iron-fortified rice, while children in the control group (n = 174) received rice with placebo. Anemia was defined as hemoglobin &lt; 11.0g/dL. Student's t-test was used to compare mean variation in hemoglobin between the groups. Hemoglobin concentration improved in both groups, with a mean increase of 0.42g/ dL in the intervention group (11.28+/-1.23g/dL to 11.75+/-1.16g/dL, p &lt; 0.001), and 0.49g/dL in controls (11.06+/-1.13g/dL to 11.51+/-1.16g/dL, p &lt; 0.001). Anemia decreased (p &lt; 0.01) in both groups (37.8% to 23.3% in the intervention group and 45.4% to 33.3% in controls), with no significant difference between the two. Hemoglobin increase was significantly higher in children that received total iron = 53.76mg from fortified rice, compared to those who received less than this cut-off value (0.94g/dl vs. 0.39g/dl, p = 0.03). The findings suggest that this type of intervention can be useful in anemia control as long as fortified food intake is adequate.

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Efeito da fortificação semanal do arroz com ferro quelato sobre a freqüência de anemia e concentração de hemoglobina em crianças de creches municipais do Rio de Janeiro, Brasil