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This study evaluated the effectiveness of supplementation with ferrous sulfate and iron bis-glycinate chelate on hemoglobin and serum ferritin levels among schoolchildren (7-11 years) of both sexes. A randomized community-based trial including 138 anemic children (hemoglobin &lt; 11.5 g/dL) was conducted in Teresina, Piauí State, Brazil. Children were assigned to two treatment groups on an individual basis. One group (n = 71) received 40 mg iron as ferrous sulfate once weekly and the other group (n = 67) received 3.8 mg of iron bis-glycinate chelate-enriched cookies, 3x/week, for 8 weeks. The interventions showed a significant increase (p &lt; 0.01) in hemoglobin levels (1.1g/dL) for children who received ferrous sulfate and 0.9 g/dl in those who received iron bis-glycinate chelate, although not significant in the inter-group comparison (p &gt; 0.05). No effect was observed on body iron for either intervention (p &gt; 0.05). Children with depleted iron stores (&lt; 15 ng/mL) at the beginning of interventions showed increased serum ferritin concentrations after 8 weeks (p &lt; 0.01), although no difference between treatments (p &gt; 0.05) was observed. The results confirm the effectiveness of the iron supplementation interventions and corroborate the use of iron salts or ferrous bisglycinate chelate on a weekly basis to overcome iron deficiency and anemia.

Efetividade de diferentes estratégias de intervenção com ferro nos níveis de hemoglobina e ferritina em escolares de Teresina, Piauí, Brasil