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Avaliou-se o uso de brânquias, fígado e rins como biomarcadores histológicos em ensaio de toxicidade crônica com o herbicida Roundup® em piauçu (Leporinus. macrocephalus). Para tanto, os animais foram expostos a 1,58mg/L, dose equivalente a 1/10 da CL50 para a espécie por 14 e 28 dias, sendo utilizados cinco animais por tratamento correspondentes aos dias 0, 14 e 28. Hemorragia e necrose hepática e congestão renal foram as alterações que apresentaram diferenças entre os animais expostos e os não expostos. Dentre os órgãos usados como biomarcadores histopatológicos, o fígado foi o que apresentou os melhores resultados, seguido pelo rim. The use of gills, liver, and kidneys as histological biomarkers was evaluated in a chronic toxicity analysis with herbicide Roundup® in piauçu (Leporinus macrocephalus). The animals were exposed to 1/10 of LC50 (1.58mg/L), during a period of 14 and 28 days. Five animals were used for treatment (days 0, 14, and 28). Hepatic hemorrhage and necrosis and renal congestion were the alterations that presented differences between exposed and non-exposed animals. Among the organs used as histological biomarkers, the liver presented the best results, followed by the kidneys

Biomarcadores histológicos: toxicidade crônica pelo Roundup em piauçu (Leporinus macrocephalus)