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As doenças cardiovasculares são responsáveis pela alta taxa de mortalidade nos países desenvolvidos e em desenvolvimento, assim, têm sido alvo de vários estudos. O objetivo deste trabalho foi avaliar as concentrações de colesterol e suas frações, triglicérides e pressão arterial em humanos. O estudo foi dividido em três tratamentos - dieta (placebo), estatina e ácidos graxos ômega-3 com dieta de 1200 kcal por dia para todos os grupos com oito pacientes cada, e vários parâmetros foram avaliados no tempo zero e 30 dias. Conclui-se que para o tratamento dieta houve diminuição de peso, colesterol total, HDL-c, triglicérides, Pressão arterial sistólica (PAS), Pressão arterial diastólica (PAD) e aumento no LDL-c. No tratamento estatina, houve redução de peso, colesterol total, LDL-c, triglicérides, PAS, PAD e aumento do HDL-c. Já no tratamento com ômega-3, constatou-se a diminuição de peso, colesterol total, LDL-c, triglicérides; aumento de PAS e PAD e níveis de HDL-c iguais.Cardiovascular diseases are responsible for the high mortality rate in many countries, therefore, they have been widely studied recently. The objective of this research was to evaluate the concentration of cholesterol and its fractions, triglycerides and blood pressure in humans. This study was divided into three treatments (placebo, statin, and ômega-3) with a 1200 calorie diet per day for all groups of eight patients. The following parameters were evaluated on day 0 and day 30: anthropometry (weight); clinical assessment (arterial pressure), and biochemistry (total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides). The findings show that in the diet treatment there was weight loss, decrease of total cholesterol, HDL-cholesterol, triglycerides, SAP, and DAP, and increase of LDL-cholesterol. In the statin treatment there was weight loss, decrease of total cholesterol, LDL-cholesterol, triglycerides, SAP, and DA, and increase of HDL-cholesterol. In the ômega-3 treatment it was verified weight loss, total cholesterol, LDL-cholesterol, and triglycerides; increase of values of SAP and DAP, and the levels of HDL-cholesterol remained constant

Efeito da dieta, estatina e ácidos graxos ômega-3 sobre a pressão arterial e a lipidemia em humanos