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Samuel MacDonald McCann was born in Houston, Texas, USA, on September 8, 1925, the only child of parents dedicated to university life. He received his basic education at Rice University, Houston. However, his interest in science developed during high school at Culver Military Academy. He obtained his MD at the Medical School of the University of Pennsylvania in 1948 in only three years, always as one of the best students in the course. During this period he published two papers in the American Journal of Physiology demonstrating the role of stress and of adrenocortical hormones in triggering hypertension. He did his internship and medical residency at Massachusetts General Hospital, Boston, where he conducted studies on the artificial kidney. Two years later he returned to the University of Pennsylvania as a Physiology Instructor and then served in the American Armed Forces at Walter Reed Hospital (Army Medical Corps), where he continued his studies on stress and on the control of vasopressin secretion. In the Department of Physiology of the University of Pennsylvania he started his pioneering studies in Neuroendocrinology, demonstrating the existence of neuropeptides secreted by the hypothalamus and responsible for the control of adenohypophyseal functions. He was the first to demonstrate the role of vasopressin in the control of ACTH secretion, the biological existence of LH-releasing factor (LHRF) in the basal middle hypothalamus, and of FSH-RF, GHRF and GHIF, the last known as somatostatin. At the University of Pennsylvania he held all the academic positions from Instructor to Full Professor of Physiology in 1964. In 1965 he was invited to be Chairman of the Department of Physiology of Tulane University, New Orleans, and of the University of Texas, Southwestern Medical School, Dallas. He chose the University of Texas, where he built one of the best Neuroendocrinology nuclei in the country. At that time, one of us (JAR) had the privilege of accompanying him from Philadelphia to DalJ. Antunes-Rodrigues1, J.C. Bedran de Castro3, C.R. Franci1, J.A. Anselmo Franci2, C.C. Pazos de Moura4, E.G. Moura5 and U. Marubayashi6 1Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, SP, Brasil 2Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto, USP, Ribeirão Preto, SP, Brasil 3Departamento de Apoio, Produção e Saúde, Faculdade de Odontologia de Araçatuba, UNESP, Araçatuba, SP, Brasil 4Instituto de Biofísica Carlos Chagas Filho, UFRJ, Rio de Janeiro, RJ, Brasil 5Departamento de Ciências Fisiológicas, Instituto de Biologia, UERJ, , Rio de Janeiro, RJ, Brasil 6Departamento de Fisiologia e Biofísica, ICB, UFMG, Belo Horizonte, MG, Brasil

A tribute to Samuel MacDonald McCann (1925-2007): in honor of one of the last pioneers of Neuroendocrinology