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Two sensitive spectrophotometric methods are described for the detn. of lansoprazole (LPZ) in bulk drug and in capsule formulation.  The methods are based on the oxidn. of lansoprazole by in situ generated bromine followed by detn. of unreacted bromine by 2 different reaction schemes.  In one procedure (method A), the residual bromine is treated with excess of iron (II), and the resulting iron (III) is complexed with thiocyanate and measured at 470 nm.  The second approach (method B) involves treating the unreacted bromine with a measured excess of iron (II) and remaining iron (II) is complexed with orthophenanthroline at a raised pH, and measured at 510 nm.  In both methods, the amt. of bromine reacted corresponds to the amt. of LPZ.  The exptl. conditions were optimized.  In method A, the absorbance is found to decrease linearly with the concn. of LPZ (r = -0.9986) where as in the method B a linear increase in absorbance occurs (r = 0.9986).  The systems obey Beer's law for 0.5-4.0 and 0.5-6.0 Î¼g mL-1 for method A and method B, resp.  The calcd. molar absorptivity values are 3.97 Ã— 104 and 3.07 Ã— 104 Î¼L/mol-1cm-1 for method A and method B, resp., and the corresponding Sandell sensitivity values are 0.0039 and 0.0013 Î¼g/cm-2.  The limit of detection (LOD) and quantification (LOQ) are also reported for both methods.  Intra-day and inter-day precision, and accuracy of the methods were established as per the current ICH guidelines.  The methods were successfully applied to the detn. of LPZ in capsules and the results tallied well with the label claim and the results were statistically compared with those of a ref. method by applying the Student's t-test and F-test.  No interference was obsd. from the concomitant substances normally added to capsules.  The accuracy and validity of the methods were further ascertained by performing recovery expts. via std.-addn. method. [on SciFinder(R)

Spectrophotometric determination of lansoprazole in pharmaceuticals using bromate-bromide mixture based on redox and complexation reactions