English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Search for better anti-leishmanial drugs is still imperative, since the current treatment with antimonials is toxic, expensive, and requires prolonged intramuscular administration (EM Netto et al. 1990 Transactions 84 : 367). All these features are serious obstacles to compliance in endemically exposed populations. Evaluation of antiparasitic drugs that are already marketed and used for other infectious diseases should be regarded as a viable, and expeditious alternative to the costly development of new compounds. Albendazole has been shown to inhibit the growth of various protozoal parasites in vitro, and was successfully used for treating immunocompromised individuals infected with microsporidial infections (R Weber et al. 1994 Clin Microbiol Rev 7: 426). Since these organisms are intracellular parasites it was speculated that an aggressive treatment schedule similar to that used in AIDS patients, could also be active against Leishmania, another intracellular protozoan parasite. To explore this possibility we used the golden hamster (Mesocricetus auratus ), which has been shown to be an adequate model for studying antiLeishmania therapy (WL Hanson et al. 1991 J Parasitol 77: 780, BL Travi et al. 1993 Transactions 87: 567). A subline of MHA inbred hamsters (n=14) was inoculated s.c. in the hindfoot with 1x10 4

Failure of Albendazole as an Alternative Treatment of Cutaneous Leishmaniasis in the Hamster Model