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The perchloro-soluble mucroptotein fraction was determined in the cells of Ehrlich ascites carcinoma on the 10th and 12th days post-inoculation of the tumor. After 3 days of a single subcutaneous dose of cyclophosphamide (200 mg/kg) the mucoprotein levels were found considerable lower. This difference was highly significant statistically. Foi determinada a fração mucoproteica percloro-solúvel nas células do carcinoma ascítico de Ehrlich, no 10º e 12º dias após a inoculação do tumor. Nos camundongos injetados com uma única dose subcutânea de ciclofosfamida (200 mg/kg) os níveis desta fração foram encontrados consideravelmente mais baixos. A análise estatística demonstrou que as diferenças observadas entre os animais controles e os tratados com ciclofosfamida foram altamente significativas

Inhibitory effect of cyclophosphamide on the biosynthesis of a perchloro-soluble protein fraction of ehrlich ascites carcinoma cells