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The impact of basic research on advances in cardiology is undisputable. Didactically and simplistically speaking, we can identify four different levels of work in this field. Firstly, it enables the development of new treatments related to cardiology; in addition, basic research provides tools for studying various aspects of cardiovascular diseases; thirdly, new concepts can be created on topics already studied, and, finally we can use basic research to study the pathophysiological mechanisms involved in different pathologies. In Brazil, the Brazilian Archives of Cardiology (ABC) play a prominent role on publications involving basic research in cardiology. Importantly, as discussed below, the journal has been contributing with expertise covering the four levels of work, as previously cited. Taking into account the development of new treatments, several recent publications have addressed this issue. Interestingly, we can identify several research areas emphasizing new treatments for cardiovascular disease. For example, the dietary manipulation was one of the main areas within the journal. Indeed, a study with animals that underwent hypercaloric diet revealed that obesity induced a decreased vascular reactivity associated to changes in the L-arginine/nitric oxide pathway 1

Impacto da pesquisa básica nos avanços da cardiologia