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1,3-5 . Prior to drug-eluting stents (DES), a strong correlation between restenosis and vessel size was recognized, with an inverse association between vessel size and angiographic restenosis; this was attributed to the disproportionately greater amount of neointimal hyperplasia (NIH) relative to the vessel caliber in smaller criteria, including lesion complexity and stent size.) At follow-up, late lumen loss (LLL), restenosis and NIH area were signifi cantly reduced with SES, and target lesions revascularization (TLR) was 3.5-fold lower in SES versus BMS patiens, a difference that did not reach statistical signifi cance. The performance of SES in small vessels has been evaluated in several randomized clinical trials and registries (Table 1). LLL, a surrogate of NIH, was signifi cantly decreased with SES compared to BMS in "small vessels" by 98.7%, 78.8%, 81%, 88.2%, and 82.2% in RAVEL, SIRIUS, E-SIRIUS, C-SIRIUS, and SES-SMART, respectively 2,5,7-10 . In Devito's study, LLL was decreased by 77.5%, p<0.001 6

Stents com eluição de sirolimus para tratamento de estenose em artérias coronárias de pequeno calibre: o que aprendemos?