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The conformation of blood pressure curve varies extremely from larger to smaller arteries due to different predominant structure and functional properties of the arterial wall along the arterial system. The simple determination of two points of the blood pressure curve, systolic and diastolic blood pressure, has been used in most of epidemiologic and genetic studies on hypertension, without taken into account the difference pro le of blood pressure curve along the arterial tree. Recently, non-invasive pulse wave analysis has identi ed measurements of arterial stiffness as an independent factor of cardiovascular risk in hypertensives. Different determinants of arterial stiffness seem to be genetically determined. Future studies on the genetics of hypertension should consider the blood pressure pro le and its main determinants.

Perfil da pressão arterial ao longo da árvore arterial e genética da hipertensão