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There is evidence that trypanosomicide drugs prevent the parasitological reactivation of Chagas' disease in patients under corticosteroid therapy. On the other hand there are few reports of clinical reactivation of this disease associated with the use of these immunosuppressive drugs. Primary chemoprophylaxis with trypanosomicide in this situation should not be recommended before being assessed by a randomized controlled trial.

revista da sociedade brasileira de medicina tropical

Benznidazol na quimioprofilaxia primária da reativação de doença de Chagas em chagásicos crônicos em uso de corticosteróides em doses imunodepressoras: há evidência suficiente para a recomendação do seu uso?