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Cardiac parasympathetic denervation during the acute phase of Trypanosoma cruzi infection is believed to play an important role in the pathogenesis o f C h ag as 'cardiopathy5. As Trypanosoma cruzi infection in mice produces myocarditis with characteristics similar to Chagas 'myocarditis in humans25, this model was chosen to investigate the sensitivity of atrial muscarinic receptors to exogenously administered acetylcholine (ACh). In a previous study10 using atria of mice chronically infected with either a reticulotropic (Y) or a myotropic (CL) strain of Trypanosoma cruzi, it was reported no significant change in the sensitivity to ACh, a result that might be due to reinnervation processes occuring after the acute phase, as shown in rats78. So, itwas decided to investigate the atrial reactivity to ACh during the acute phase of Trypanosoma cruzi infection in mice. The CL strain was choses because it induces a more severe myocarditis than the Y strain1. Albino mice weighing 24-32 g were inoculated intraperitonally with 200 trypamastigotes/g of a CL strain of Trypanosoma cruzi. All infected animals exhibited blood parasites after infection, as determined by means of microscopic examination of a drop of blood 14 days after infection. After 30 days of infection (acute phase) the animals were killed for in vitro recording of the effects of ACh. Age-matched

revista da sociedade brasileira de medicina tropical

Absence of hypersensitivity to the negative chronotropic effect of acetylcholine in the atria of mice acutely infected with Trypanosoma cruzi, cl strain