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There is a considerable interval between the exposure to antigens and the first appearance of specific antibodies in mammals, at birth. This interval is occupied by the transmission of maternal antibodies. Specifically in mice, little antibody is transferred by the yolk sac and placenta, the passive transmission is almost exclusively postnatal by means of absorption of lacteal secretion in the intestine. In the proximal small intestine, there is a selective absorption of IgG, which is bound to an intestinal Fc fragment receptor, interna­ lized by endocytosis and then absorbed by the vascular system. In the distal small intestine little selectivity is found. At day 16 after birth the transmission of IgG ceases, the receptors disappear from the gut, although system and the hepatic granulomatous lesions were studied in order to evaluate the effects of maternal transmission of schistosomal antigens and antibodies to offspring of Schistosoma mansoni infected mice in relation with the time of mother infection. C57BL/6 female mice 8-10 weeks old were infected subcutaneously ( 10 ± 5 cercariae per mouse) and then challenged five times each two weeks**. Infected females were separated in two groups of ten. In the first group, the females were mated ten days following the third inoculation, breeding at the 60 th day after the first inoculation. The second group was mated the day after the last inoculation, breeding at the 80th day after the first inoculation. The mice bom of the first group formed the experimental group A and the mice bom of the second formed the experimental group B. The control group was formed by mice bom of non-infected females. Offspring of infected and noninfected females were infected at 0-4 days by placing each one in a Petri dish, containing 20 ± 2 cercariae/5

Morphometric study of hepatic granuloma in offspring of Schistosoma mansoni infected mice