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This thesis describes the importance of acute bacterial infections of the lower respiratory tract on the morbidity and mortality in young children from warm-climate countries. Acute lower respiratory tract infection (ALRI) is the major cause of preventable death in children worldwide and responsible for 4 million childhood deaths every year. Most of these deaths are caused by pneumonia and occur in young children in the poorest countries of the world, where fatality rates of severe pneumonia in children under 5 years of age are substantially higher than those in industrialized countries. Severe ALRI are also much more common in poor than in rich countries and the reasons for this high mortality and morbidity are not fully understood but poverty, malnutrition, coincident diseases (HIV infection), low levels of health care and the relative greater role of bacterial pathogens in the etiology of pneumonia in low-income countries may be important factors.

revista do instituto de medicina tropical de são paulo

Acute bacterial infections of the lower respiratory tract: epidemiological, clinicopathologic and molecular-genetic findings in children from warm-climate countries