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The hepatic changes observed in liver specimen from either biopsy or necropsy of 47 patients with visceral leishmaniasis permited us to define three different histopathological patterns of involvement: typical, nodular, and fibrogenic. These patterns seem to be representative of different evolutive stages of the hepatic involvement in the disease either towards a more benign evolution or to more chronic stage with fibrosis and "cirrhosis". These histopathological evolutive stages are related to the prognosis of the disease. As alterações hepáticas observadas no fígado em material de biópsia ou necropsia de 47 pacientes com leishmaniose visceral nos permitiu definir três padrões histopatológicos diferentes de acometimento hepático: típico, nodular e fibrogênico. Estes padrões parecem ser representativos de diferentes formas evolutivas do acometimento hepático na doença para uma evolução mais benigna ou para uma evolução mais crônica com fibrose e "cirrose". Estas formas histopatológicas evolutivas estão relacionadas ao prognóstico da doença

Histopathological patterns of the liver involvement in visceral leishmaniasis