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. Children and adult exposure to SecondHand Smoke (SHS) may occur in government offices, work and public places as well as in vehicles. Nevertheless, SHS is par ticularly important at home. High exposure levels in children may be the main reason to prevent parents and other family members from smoking at home. This study aims at estab lishing SHS levels by measuring biomakers in serum in pairs of parents and their younger than five years old children in Mexico, included in the 2000 National Health Survey. Material and Methods. Seventy-six parents-children pairs were taken from households with non smokers adults, as well as 83 pairs with adult smokers at home. Selection was limited to the adult population in households with children under five years old. Serum samples were analyzed through liquid chromatographic. Correlation exposure models between parents-children pairs were built and stratified according to parents’ background concerning smoking. Results. In the smokers group, people with more than 15ng/mL of cotinine metabolites in serum showed prevalence of 100%. Minimum quantification was 18.50 and maximum 221.5ng/mL. In adults, cotinine metabolite levels in serun were 50 times higher in smokers (107.4ng/mL), than in non smokers (1.99 ng/mL). Concerning 3-hydroxycotinine, something similar was ob served (0.60 in non smokers vs. 33.50 ng/mL in smokers). A significant difference three times higher in cotinine levels (0.10 vs. 0.60ng/mL) and 3-hydroxycotinine (0.06 vs. 0.19ng/mL) was found in those children with, at least, one of both parents who smoked. Conclusions. It is worthwhile noting that although there is a significant difference in ETS in children with both

Elevada concentración de metabolitos de cotinina en hijos de padres fumadores